S0278
(±)-Sotalol hydrochloride
≥98% (TLC), powder, β-Adrenoceptor antagonist
Sinónimos:
N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride
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About This Item
Fórmula empírica (notación de Hill):
C12H20N2O3S · HCl
Número de CAS:
Peso molecular:
308.82
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Nombre del producto
(±)-Sotalol hydrochloride, ≥98% (TLC), powder
Nivel de calidad
Ensayo
≥98% (TLC)
Formulario
powder
color
white to off-white
solubilidad
H2O: 20 mg/mL
emisor
Bayer
cadena SMILES
Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
InChI
1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
Clave InChI
VIDRYROWYFWGSY-UHFFFAOYSA-N
Información sobre el gen
human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)
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Aplicación
(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.
Acciones bioquímicas o fisiológicas
Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.
Características y beneficios
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Aplicación
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Gloves
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Chromatograms
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