L7757

Lidocaine

≥98% (GC), powder, neuroprotective agent

• Sinónimos: 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine
• Fórmula empírica (notación de Hill): C₁₄H₂₂N₂O
• Número de CAS: 137-58-6
• Peso molecular: 234.34
• Número CE: 205-302-8
• Número MDL: MFCD00026733
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24896480
• NACRES: NA.77

Propiedades

• product name: Lidocaine, powder
• formulario: powder
• cadena SMILES: CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
• Clave InChI: NNJVILVZKWQKPM-UHFFFAOYSA-N
• Información sobre el gen: human ... CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Scnn1a(25122)

Descripción

Descripción general

Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.

Aplicación

Lidocaine may be used for drug testing and for voltage clamp experiments.

Acciones bioquímicas o fisiológicas

Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na⁺) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves