P1269

Phorbol 12,13-dibutyrate

≥98% (TLC), powder, PKC activator

• Sinónimos: PDBu
• Fórmula empírica (notación de Hill): C₂₈H₄₀O₈
• Número de CAS: 37558-16-0
• Peso molecular: 504.61
• Beilstein: 6551234
• Número MDL: MFCD00036783
• Código UNSPSC: 12352211
• ID de la sustancia en PubChem: 24898178
• NACRES: NA.77

Propiedades

• Nombre del producto: Phorbol 12,13-dibutyrate, ≥98% (TLC), powder
• Nivel de calidad: 100
• Ensayo: ≥98% (TLC)
• Formulario: powder
• color: clear light yellow, film
• solubilidad: H₂O: 30 μM; DMSO: soluble; acetone: soluble; ethanol: soluble
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)[C@H]2C=C(C)C3=O)[C@@H]4C(C)(C)[C@]14OC(=O)CCC
• InChI: 1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
• Clave InChI: BQJRUJTZSGYBEZ-YVQNUNKESA-N
• Información sobre el gen: mouse ... Prkcd(18753)

Descripción

Aplicación

Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.

Acciones bioquímicas o fisiológicas

Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.

Características y beneficios

Less hydrophobic then PMA, making it easier to wash out of cells in tissue culture.

Precaución

Photosensitive

Reconstitución

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS05
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330,H314,H317,H334,H351
• Consejos de prudencia: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves