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D5318

DCP-LA

Name: DCP-LA
Brand: SIGMA

≥95% (HPLC), oil

Sinónimos:

2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid, FR 236924

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About This Item

Fórmula empírica (notación de Hill):

C₂₀H₃₆O₂

Número de CAS:

28399-31-7

Peso molecular:

308.50

Número MDL:

MFCD09265251

Código UNSPSC:

12352200

ID de la sustancia en PubChem:

24724463

NACRES:

NA.77

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Sigma-Aldrich

128708

Ferulic acid

Nivel de calidad

100

Análisis

≥95% (HPLC)

formulario

oil

color

clear

solubilidad

DMSO: >2 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

CCCCCC1CC1CC2CC2CCCCCCCC(O)=O

InChI

1S/C20H36O2/c1-2-3-7-10-16-13-18(16)15-19-14-17(19)11-8-5-4-6-9-12-20(21)22/h16-19H,2-15H2,1H3,(H,21,22)

Clave InChI

CONYTTFKIUJZOF-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

DCP-LA is a selective PKC-epsilon (PKC-ε) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activated PKC in PC-12 cells in a concentration (10 nM-100 μM)-dependent manner, with the maximal effect at 100 nM. DCP-LA has over a 7-fold greater potency for activation of PKC-ε over other PKC isozymes.

Características y beneficios

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site.

Takeshi Kanno et al.

Journal of lipid research, 47(6), 1146-1156 (2006-03-08)

This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bonds, on protein kinase C (PKC) activity. In the in situ PKC assay with reverse-phase high-performance liquid chromatography, DCP-LA

Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.

Takahiro Yaguchi et al.

Neuroreport, 17(1), 105-108 (2005-12-20)

In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the

Sasanquasaponin induces increase of Cl‑/HCO3‑ exchange of anion exchanger 3 and promotes intracellular Cl‑ efflux in hypoxia/reoxygenation cardiomyocytes.

Ling-Yu Qiu et al.

Molecular medicine reports, 16(3), 2953-2961 (2017-07-06)

Anion exchanger 3 (AE3) is known to serve crucial roles in maintaining intracellular chloride homeostasis by facilitating the reversible electroneutral exchange of Cl‑ for HCO3‑ across the plasma membrane. Our previous studies reported that sasanquasaponin (SQS) can inhibit hypoxia/reoxygenation (H/R)‑induced

Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway.

Joshua H K Tam et al.

PloS one, 11(10), e0161445-e0161445 (2016-10-25)

The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase. While nascent APP is

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