53300

Histamine dihydrochloride

≥99.0% (AT), powder or crystals, endogenous histamine receptor agonist

• Sinónimos: 2-(4-Imidazolyl)ethylamine dihydrochloride
• Fórmula empírica (notación de Hill): C₅H₉N₃ · 2HCl
• Número de CAS: 56-92-8
• Peso molecular: 184.07
• Beilstein: 3624116
• Número CE: 200-298-4
• Número MDL: MFCD00012703
• Código UNSPSC: 12352116
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 329757931
• NACRES: NA.77

Propiedades

• product name: Histamine dihydrochloride, ≥99.0% (AT)
• Análisis: ≥99.0% (AT)
• formulario: powder or crystals
• residuo de ign.: ≤0.2%
• pérdida: ≤0.2% loss on drying, 20 °C (HV)
• mp: 244-247 °C; 249-252 °C (lit.)
• solubilidad: H₂O: 0.1 g/mL, clear, colorless
• trazas de anión: sulfate (SO₄^2-): ≤200 ppm
• trazas de catión: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• cadena SMILES: Cl[H].Cl[H].NCCc1c[nH]cn1
• InChI: 1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
• Clave InChI: PPZMYIBUHIPZOS-UHFFFAOYSA-N
• Información sobre el gen: human ... HRH1(3269)

Descripción

Descripción general

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats.

Acciones bioquímicas o fisiológicas

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H₂ histamine receptor.

Otras notas

Substrate for the assay of histamine-N-methyltransferase (EC 2.1.1.8); Ion-pair extraction of histamine from biological fluids for its determination by HPLC with fluorescence detection

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H315,H317,H319,H334,H335
• Consejos de prudencia: P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves