P5780

Putrescine dihydrochloride

powder, BioReagent, suitable for cell culture

• Sinónimos: 1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride
• Fórmula lineal: NH₂(CH₂)₄NH₂ · 2HCl
• Número de CAS: 333-93-7
• Peso molecular: 161.07
• Beilstein: 3906680
• Número CE: 206-375-9
• Número MDL: MFCD00012526
• Código UNSPSC: 12352207
• ID de la sustancia en PubChem: 24898707
• NACRES: NA.75

Propiedades

• origen biológico: microbial; synthetic
• Nivel de calidad: 200
• Línea del producto: BioReagent
• Análisis: ≥97% (TLC)
• formulario: powder
• técnicas: cell culture | mammalian: suitable
• mp: 280 °C (dec.) (lit.)
• solubilidad: H₂O: 100 mg/mL
• cadena SMILES: Cl[H].Cl[H].NCCCCN
• InChI: 1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
• Clave InChI: XXWCODXIQWIHQN-UHFFFAOYSA-N

Descripción

Descripción general

Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.

Aplicación

Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.

Acciones bioquímicas o fisiológicas

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.

Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress. It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants. It serves as an attractant for predators.

Información de seguridad

• Pictogramas: GHS06,GHS05
• Palabra de señalización: Danger
• Frases de peligro: H302,H311,H314,H330
• Consejos de prudencia: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 1
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves