S2626

Spermidine

≥99% (GC)

• Sinónimos: 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Fórmula lineal: NH₂(CH₂)₃NH(CH₂)₄NH₂
• Número de CAS: 124-20-9
• Peso molecular: 145.25
• Beilstein: 1698591
• Número CE: 204-689-0
• Número MDL: MFCD00008229
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24899529
• NACRES: NA.32

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 200
• Ensayo: ≥99% (GC)
• Formulario: solid or liquid (clear)
• impurezas: DNase, none detected; RNase, none detected; protease, none detected
• índice de refracción: n20/D 1.479 (lit.)
• mp: 22-25 °C
• solubilidad: water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
• densidad: 0.925 g/mL at 25 °C (lit.)
• temp. de almacenamiento: room temp
• cadena SMILES: NCCCCNCCCN
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• Clave InChI: ATHGHQPFGPMSJY-UHFFFAOYSA-N
• Información sobre el gen: rat ... Ppm1a(24666)

Descripción

Descripción general

Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources.

The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.

Aplicación

Spermidine has been used:

• in the preparation of 5x transcription buffer
• in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
• as a standard in the analytical study of rat brain polyamines (185)

Acciones bioquímicas o fisiológicas

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T₄ polynucleotide kinase activity.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Precaución

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Otras notas

Store under inert gas. Air sensitive; strongly hygroscopic.

Información de seguridad

• Pictogramas: GHS05
• Palabra de señalización: Danger
• Frases de peligro: H314
• Consejos de prudencia: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Clasificaciones de peligro: Eye Dam. 1 - Skin Corr. 1B
• Código de clase de almacenamiento: 8A - Combustible corrosive hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 233.6 °F - closed cup
• Punto de inflamabilidad (°C): 112 °C - closed cup
• Equipo de protección personal: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter