85558

Spermidine

BioUltra, for molecular biology, ≥99.5% (GC)

• Sinónimos: SPD, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Fórmula lineal: NH₂(CH₂)₃NH(CH₂)₄NH₂
• Número de CAS: 124-20-9
• Peso molecular: 145.25
• Beilstein: 1698591
• Número CE: 204-689-0
• Número MDL: MFCD00008229
• Código UNSPSC: 12352116
• ID de la sustancia en PubChem: 57653053
• NACRES: NA.26

Propiedades

• grado: for molecular biology
• Nivel de calidad: 200
• Línea del producto: BioUltra
• Análisis: ≥99.5% (GC)
• condiciones de almacenamiento: (Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)
• técnicas: ChIP: suitable; buffer exchange: suitable
• impurezas: DNases, none detected; RNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected
• índice de refracción: n20/D 1.479 (lit.)
• pH: 12.0-13.5 (25 °C, 1 M in H₂O)
• solubilidad: H₂O: 1 M at 20 °C, clear, colorless
• densidad: 0.925 g/mL at 25 °C (lit.)
• trazas de anión: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• trazas de catión: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 1 M in H₂O
• Absorción UV: λ: 260 nm A_max: 0.1; λ: 280 nm A_max: 0.05
• cadena SMILES: NCCCCNCCCN
• idoneidad: suitable for molecular biology
• aplicaciones: advanced drug delivery; genomic analysis
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• Clave InChI: ATHGHQPFGPMSJY-UHFFFAOYSA-N
• Información sobre el gen: rat ... Ppm1a(24666)

Descripción

Descripción general

Spermidine is a polyamine and a trivalent organic cation.Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.

Aplicación

Spermidine has been used:

• as a component of chromosome isolation buffer
• as a component of transcription buffer
• as a component of homogenization buffer

Acciones bioquímicas o fisiológicas

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis.

Características y beneficios

• Versatile and adaptable for a wide variety of laboratory and research applications
• Suitable for Molecular Biology and Biochemical research
• Free from DNase, RNase, NICKase, and protease
• Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
• Tested for trace levels of Anions and Cations

Precaución

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Nota de análisis

liquid or solid

Otras notas

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In first strand cDNA synthesis; Effect on endonuclease inhibition by agarose contaminants

Información de seguridad

• Pictogramas: GHS05
• Palabra de señalización: Danger
• Frases de peligro: H314
• Consejos de prudencia: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Clasificaciones de peligro: Eye Dam. 1 - Skin Corr. 1B
• Código de clase de almacenamiento: 8A - Combustible corrosive hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 233.6 °F - closed cup
• Punto de inflamabilidad (°C): 112 °C - closed cup
• Equipo de protección personal: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter