911763

C5 Lenalidomide-PEG₁-piperazine hydrochloride

≥95%

• Sinónimos: N-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)-3-(2-(piperazin-1-yl)ethoxy)propanamide hydrochloride, C5 Lenalidomide conjugate, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader
• Fórmula empírica (notación de Hill): C₂₂H₂₉N₅O₅ · xHCl
• Peso molecular: 443.50 (free base basis)
• Código UNSPSC: 12352101

Propiedades

• ligand: C5 Lenalidomide
• Análisis: ≥95%
• formulario: powder or crystals
• idoneidad de la reacción: reagent type: ligand-linker conjugate
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(CCOCCN4CCNCC4)=O)=CC=C31.Cl

Descripción

Aplicación

Protein degrader building block C5 Lenalidomide-PEG₁-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector, a rigid linker, and a pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Otras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable