910554

(S,R,S)-AHPC-PEG₆-butyl CO₂H

≥95%

• Sinónimos: (S)-3-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-2,2-dimethyl-5-oxo-7,10,13,16,19,22-hexaoxa-4-azanonacosan-29-oic acid, (S,R,S)-AHPC-2-2-2-2-2-2-6-Acid, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate
• Fórmula empírica (notación de Hill): C₄₁H₆₄N₄O₁₂S
• Peso molecular: 837.03

Propiedades

• ligand: VH032
• Análisis: ≥95%
• formulario: (Liquid or Semi-Solid or Paste or Solid)
• idoneidad de la reacción: reactivity: amine reactive; reagent type: ligand-linker conjugate
• grupo funcional: carboxylic acid
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCOCCOCCOCCOCCCCCCC(O)=O.Cl

Descripción

Aplicación

Protein degrader building block (S,R,S)-AHPC-PEG₆-Butyl CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Otras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable