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1711202

USP

Verapamil -hydrochlorid

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

(±)-Verapamil -hydrochlorid, 5-[N-(3,4-Dimethoxyphenylethyl)-methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitril -hydrochlorid

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About This Item

Lineare Formel:
(CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
CAS-Nummer:
152-11-4
Molekulargewicht:
491.06
Beilstein:
3647093
EG-Nummer:
205-800-5
MDL-Nummer:
MFCD00055208
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329751490
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

verapamil

Hersteller/Markenname

USP

mp (Schmelzpunkt)

142 °C (dec.) (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

SMILES String

Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

InChI

1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChIKey

DOQPXTMNIUCOSY-UHFFFAOYSA-N

Angaben zum Gen

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Verapamil hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Verapamil Hydrochloride Injection
  • Verapamil Hydrochloride Tablets
  • Verapamil Hydrochloride Extended-Release Capsules
  • Verapamil Hydrochloride Extended-Release Tablets
  • Verapamil Hydrochloride Compounded Oral Solution
  • Verapamil Hydrochloride Compounded Oral Suspension

Biochem./physiol. Wirkung

α1-Adrenozeptor-Antagonist, L-Typ-Calcium-Kanal-Blocker. Hemmt L-type Ca2+-Kanäle in glatter und Herzmuskulatur, induziert in vitro Apoptose von humanen primären und metastatischen Kolonadenokarzinom-Zellen. Erhöht basale ATPase-Aktivität von Pgp. Substrat von CYP3A4 und CYP2C6.

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

Piktogramme

Skull and crossbonesEnvironment
GHS06,GHS09

Signalwort

Danger

H-Sätze

H301,H411

Gefahreneinstufungen

Acute Tox. 3 Oral - Aquatic Chronic 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Cisaprid United States Pharmacopeia (USP) Reference Standard

USP

1134120

Cisaprid

PD 169316 ≥98% (HPLC), solid

Sigma-Aldrich

P9248

PD 169316

BIX ≥98% (HPLC)

Sigma-Aldrich

SML1073

BIX

Nifedipin ≥98% (HPLC), powder

Sigma-Aldrich

N7634

Nifedipin

Sigma-Aldrich

Sigma-Aldrich

5.04314

Bortezomib

bisBenzimid H 33342 ≥98% (HPLC and TLC)

Sigma-Aldrich

B2261

bisBenzimid H 33342

S H Baky et al.
Pharmacotherapy, 2(6), 328-353 (1982-11-01)
Verapamil hydrochloride, a prototype calcium antagonist, is now marketed in the United States for the acute treatment of supraventricular tachyarrhythmias and for chronic management of vasospastic and chronic stable angina. It inhibits the slow inward channel in in the heart
S Izdes et al.
Acta clinica Belgica, 69(2), 116-119 (2014-04-15)
Verapamil intoxication is a life-threatening condition that often presents with severe hemodynamic instability and requires vasopressor support. There are also documented case reports of the development of non-cardiogenic pulmonary oedema after verapamil overdose. However, the exact mechanisms responsible for pulmonary
Soon Hyung Park et al.
The Laryngoscope, 124(6), 1444-1451 (2013-10-25)
We investigated whether the round window membrane (RWM) vibration can facilitate dexamethasone perfusion via the RWM in patients with sudden hearing loss. Prospective study. We first performed an in vitro study using a semipermeable membrane. In the subsequent in vivo
Anurag Pandey et al.
The Journal of physiology, 592(16), 3537-3557 (2014-06-08)
The subiculum is a structure that forms a bridge between the hippocampus and the entorhinal cortex (EC), and plays a major role in the memory consolidation process. Here, we demonstrate spike-timing-dependent plasticity (STDP) at the proximal excitatory inputs on the
Yasuo Uchida et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 578-588 (2014-06-21)
The aim of this study was to investigate whether in vivo drug distribution in brain in monkeys can be reconstructed by integrating four factors: protein expression levels of P-glycoprotein (P-gp)/multidrug resistance protein 1 at the blood-brain barrier (BBB), in vitro
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