M5793

3-Morpholinosydnonimine hydrochloride

(consistent with structure, NMR)

• Synonym(e): 3-(4-Morpholinyl)sydnone imine hydrochloride, Linsidomine hydrochloride, SIN-1 hydrochloride
• Empirische Formel (Hill-System): C₆H₁₀N₄O₂ · HCl
• CAS-Nummer: 16142-27-1
• Molekulargewicht: 206.63
• MDL-Nummer: MFCD00214332
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24897048
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Lagertemp.: −20°C
• SMILES String: Cl[H].[NH-]c1c[n+](no1)N2CCOCC2
• InChI: 1S/C6H10N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5,7H,1-4H2;1H
• InChIKey: NCGICGYLBXGBGN-UHFFFAOYSA-N

Beschreibung

Anwendung

3-Morpholinosydnonimine hydrochloride has been used:

• as a peroxynitrite donor standard to study the accumulation of peroxynitrite in Arabidopsis thaliana
• to study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cells
• as a ROS to study its effects on mouse embryonic fibroblasts

Biochem./physiol. Wirkung

3-Morpholinosydnonimine participates in the inhibition of cysteine proteases.

Liberates nitric oxide (NO) spontaneously when in solution, activating guanylyl cyclase and causing an increase in cyclic-GMP. This product is a vasodilator and inhibits platelet aggregation. Using molecular oxygen, it generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)