T4425

(6R)-5,6,7,8-Tetrahydrobiopterin -dihydrochlorid

≥98% (HPLC), powder

• Synonym(e): (6R)-BH₄
• Empirische Formel (Hill-System): C₉H₁₅N₅O₃ · 2HCl
• CAS-Nummer: 69056-38-8
• Molekulargewicht: 314.17
• MDL-Nummer: MFCD00891665
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277922
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: (6R)-5,6,7,8-Tetrahydrobiopterin -dihydrochlorid,
• Qualitätsniveau: 200
• Löslichkeit: water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Lagertemp.: −20°C
• SMILES String: Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)NC(N)=N2
• InChI: 1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
• InChIKey: RKSUYBCOVNCALL-NTVURLEBSA-N
• Angaben zum Gen: human ... PAH(5053)

Beschreibung

Allgemeine Beschreibung

Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase.

Anwendung

(6R)-BH₄ has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH₄ has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay.

Biochem./physiol. Wirkung

Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis.

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis and Nitric Oxide Synthases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride ((6R)-BH₄ ) is soluble in oxygen free water at 19.60 - 20.40 mg/ml and yields a clear to slightly hazy, colorless to faint yellow solution.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable