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G1660

Sigma-Aldrich

Galanthamine hydrobromide from Lycoris sp.

≥94% (HPLC)

Synonym(e):

Galantamine hydrobromide

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About This Item

Empirische Formel (Hill-System):
C17H21NO3 · HBr
CAS-Nummer:
1953-04-4
Molekulargewicht:
368.27
EG-Nummer:
217-780-5
MDL-Nummer:
MFCD00067672
UNSPSC-Code:
12352116
PubChem Substanz-ID:
24895074
NACRES:
NA.32

Biologische Quelle

plant (Ungeria victoris)

Qualitätsniveau

100

Assay

≥94% (HPLC)

Form

powder

mp (Schmelzpunkt)

270 °C

Löslichkeit

DMSO: soluble 10 mg/mL, clear, colorless
water: soluble 20 mg/mL, clear, colorless

Lagertemp.

−20°C

SMILES String

Br[H].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24

InChI

1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1

InChIKey

QORVDGQLPPAFRS-XPSHAMGMSA-N

Angaben zum Gen

human ... ACHE(43)

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Allgemeine Beschreibung

Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer′s disease (AD).

Anwendung

Galanthamine hydrobromide from Lycoris sp. has been used-
  • as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE
  • as a positive control in the screening of AChE inhibitors
  • as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides

Biochem./physiol. Wirkung

Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

P-Sätze

P301 + P310

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Sony Pandey et al.
Microbial cell factories, 13(1), 24-24 (2014-02-18)
Acetylcholinesterase (AChE) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. The inhibitors have a significant pharmacological role in neurodegenerative diseases like Alzheimer's and Parkinson's etc. Although plants have been a significant
Muhammad Ayaz et al.
BMC complementary and alternative medicine, 14, 145-145 (2014-06-03)
We investigated Polygonum hydropiper L. (P. hydropiper) for phenolic contents, antioxidant, anticholinesterase activities, in an attempt to rationalize its use in neurological disorders. Plant crude extract (Ph.Cr), its subsequent fractions: n-hexane (Ph.Hex), chloroform (Ph.Chf), ethyl acetate (Ph.EtAc), n-Butanol (Ph.Bt), aqueous
Bin Hao et al.
Molecules (Basel, Switzerland), 18(3), 2458-2468 (2013-02-27)
Phytochemical investigation of the 80% ethanol extract of the bulbs of Lycoris radiata resulted in the isolation of five new Amaryllidaceae alkaloids: (+)-5,6-dehydrolycorine (1), (+)-3α,6β-diacetyl-bulbispermine (2), (+)-3α-hydroxy-6β-acetyl- bulbispermine (3), (+)-8,9-methylenedioxylhomolycorine-N-oxide (5), and 5,6-dihydro-5- methyl-2-hydroxyphenanthridine (7), together with two known compounds
Petra Krejčová et al.
Journal of ethnopharmacology, 154(1), 176-182 (2014-04-12)
Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia. It is frequently used in folk medicine for the treatment of a variety of disorders, including inflammation and stress. Antiinflammatory and neurological activities of pyrithione
Lars Sonde et al.
PloS one, 8(2), e57161-e57161 (2013-02-26)
It is largely unknown how the medical treatment of patients diagnosed with dementia is followed up in primary care. Therefore, we studied patient medical records from two dementia clinics and from the referring primary care centres. A retrospective study of
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