711489

1-Hydroxybenzotriazol Hydrat

wetted with not less than 20 wt. % water, 97% dry basis

• Synonym(e): HOBt Hydrat
• Empirische Formel (Hill-System): C₆H₅N₃O · xH₂O
• CAS-Nummer: 123333-53-9
• Molekulargewicht: 135.12 (anhydrous basis)
• Beilstein: 4515
• EG-Nummer: 219-989-7
• MDL-Nummer: MFCD00065690
• UNSPSC-Code: 12352000
• PubChem Substanz-ID: 329763060
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 97% dry basis
• Form: powder
• Qualität: wetted with not less than 20 wt. % water
• Zusammensetzung: Water content, ~20%
• Eignung der Reaktion: reaction type: Addition Reactions
• mp (Schmelzpunkt): 155-158 °C (lit.)
• Löslichkeit: DMF: 0.1 g/mL, clear
• SMILES String: [H]O[H].On1nnc2ccccc12
• InChI: 1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
• InChIKey: PJUPKRYGDFTMTM-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

1-Hydroxybenzotriazolehydrate (HOBt hydrate) is a hydrated form of HOBt. HOBt is a nucleophilic additive commonly used in synthetic chemistry. It is widely employed as acatalyst or stoichiometric additive to accelerate nucleophilic acyl substitution reactions, specifically amidations. Additionally, it is also used in the synthesis of peptides and nucleotides.

Anwendung

1-Hydroxybenzotriazole hydrate is used as an additive:

• In the oligonucleotide couplings.
• In the preparation of poly(ethylene glycol)methyl ether-grafted CTS (mPEG-g-CTS).

1-Hydroxybenzotriazole hydrate can also be used:

• In the solid phase peptide synthesis on TCNEO(tetracyanoethylene oxide)-modified graphite.

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H207,H319,H412
• P-Sätze: P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
• Gefahreneinstufungen: Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
• Lagerklassenschlüssel: 4.1A - Other explosive hazardous materials
• WGK: WGK 1
• Flammpunkt (°F): 314.6 °F
• Flammpunkt (°C): 157 °C
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges