157260

1-Hydroxybenzotriazol Hydrat

98% dry basis wetted with not less than 14 wt. % water, for peptide synthesis

• Synonym(e): HOBt Hydrat
• Empirische Formel (Hill-System): C₆H₅N₃O · xH₂O
• CAS-Nummer: 123333-53-9
• Molekulargewicht: 135.12 (anhydrous basis)
• Beilstein: 4515
• EG-Nummer: 219-989-7
• UNSPSC-Code: 12352000
• PubChem Substanz-ID: 24849666
• NACRES: NA.22

Eigenschaften

• product name: 1-Hydroxybenzotriazol Hydrat, wetted with not less than 14 wt. % water, 98% dry basis
• Qualitätsniveau: 200
• Assay: 98% dry basis
• Form: solid
• Qualität: synthesis grade
• Eignung der Reaktion: reaction type: Addition Reactions
• mp (Schmelzpunkt): 155-158 °C (lit.)
• Anwendung(en): peptide synthesis
• SMILES String: [H]O[H].On1nnc2ccccc12
• InChI: 1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
• InChIKey: PJUPKRYGDFTMTM-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

1-Hydroxybenzotriazole hydrate is a derivative of benzotriazole primarily used as a coupling reagent in peptide synthesis.

Anwendung

1-Hydroxybenzotriazole hydrate can be used as a reagent:

• To synthesize β-peptides via microwave-assisted amino acid coupling.
• In the spot synthesis of glycopeptides.

It can also be used as a deprotection agent for the removal of Fmoc (9-fluorenylmethoxycarbonyl) protecting group.

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H207,H319,H412
• P-Sätze: P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
• Gefahreneinstufungen: Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
• Zusätzliche Gefahrenhinweise: EUH044
• Lagerklassenschlüssel: 4.1A - Other explosive hazardous materials
• WGK: WGK 1
• Flammpunkt (°F): 314.6 °F
• Flammpunkt (°C): 157 °C