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Gastro retention using polymer cocoons.

Gastro retention using polymer cocoons.

Artificial cells, nanomedicine, and biotechnology (2014-08-01)

Julien Arnold, David Hunkeler

ABSTRACT

A gastro-retentive capsule has been prepared which is retained in the stomach for a period of 24h, providing a vehicle for the controlled delivery to the upper intestines. These "gastro cocoons" can resist passage through the sphincter of the stomach, and can retain a high drug payload (30%). They are made from oppositely charged polyelectrolytes and can swell to twice their initial volume. They are strong and also can resist 550 N of compressive force. They are based on filled pharmaceutical capsules which are visible to X-rays. Using ambroxol hydrochloride as a model drug linear, zero-order, release curves were obtained.

MATERIALI

N° Catalogo

Marchio

Descrizione del prodotto

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Acetone, ACS reagent, ≥99.5%

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Acido cloridrico, ACS reagent, 37%

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Acetone, suitable for HPLC, ≥99.9%

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Acido cloridrico, ACS reagent, 37%

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Acetone, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%

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Cloruro di idrogeno, 4.0 M in dioxane

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Acido cloridrico, 1.0 N, BioReagent, suitable for cell culture

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Acido cloridrico, meets analytical specification of Ph. Eur., BP, NF, fuming, 36.5-38%

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Acido cloridrico, 37 wt. % in H₂O, 99.999% trace metals basis

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Acido cloridrico, 36.5-38.0%, BioReagent, for molecular biology

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Cloruro di idrogeno, 2.0 M in diethyl ether

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Acido cloridrico, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., fuming, ≥37%, APHA: ≤10

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Acetone, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)

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Chloromethane solution, 200 μg/mL in methanol, analytical standard

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Acetone, suitable for HPLC, ≥99.8%

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Acetone, ACS reagent, ≥99.5%

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Acetone, United States Pharmacopeia (USP) Reference Standard

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Hydrogen chloride, ReagentPlus^®, ≥99%

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