V900429
N-acetil-L-cisteina
98%, Vetec™
Sinonimo/i:
LNAC, NAC
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About This Item
Formula condensata:
HSCH2CH(NHCOCH3)CO2H
Numero CAS:
Peso molecolare:
163.19
Beilstein:
1724426
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
Prodotti consigliati
Nome del prodotto
N-acetil-L-cisteina, Vetec™, reagent grade, 98%
Grado
reagent grade
Nome Commerciale
Vetec™
Saggio
98%
Stato
powder
Colore
white to off-white
Punto di fusione
106-108 °C (lit.)
applicazioni
cell analysis
Temperatura di conservazione
2-8°C
Stringa SMILE
CC(=O)N[C@@H](CS)C(O)=O
InChI
1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
PWKSKIMOESPYIA-BYPYZUCNSA-N
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Applicazioni
- Antioxidant Assay Development: N-Acetyl-L-cysteine (NAC) is used in the metabolic activation and assessment of cytotoxicity of gramine mediated by CYP3A, showcasing its importance in biochemical assays that measure oxidative stress, a critical factor in IVD reagent development (Gao et al., 2024).
- Cell Differentiation and NF-κB Inhibition: NAC′s role extends to inducing oxidative stress and inhibiting NF-κB pathways, which is crucial for the differentiation of cells in AML treatment. This application demonstrates NAC′s utility in clinical diagnostic reagents aimed at cancer treatment and research (Silva et al., 2024).
- Liver Injury Alleviation: Highlighting its therapeutic applications, NAC is used in alleviating acetaminophen overdose-induced liver injury, underlining its potential use in clinical settings and importance in developing therapeutic IVD assays (Chen et al., 2024).
- Enhanced Cancer Treatment Efficacy: Employed in combination therapies, NAC is used to treat posterior gastric pseudomyxoma peritonei, offering insights into its role as a biochemical agent that enhances the efficacy of cancer treatments in diagnostic and therapeutic applications (Sun et al., 2024).
- Regulation of Cell Cycle and Autophagy: NAC′s interactions with 1-Methoxyisobrassinin in ovarian cancer cells illustrate its capability to modulate cell cycle regulation, apoptosis, and autophagy, underpinning its significant role in the development of biomarker detection assays and other IVD products (Zigová et al., 2024).
Azioni biochim/fisiol
Agente antiossidante e mucolitico. Incrementa gli agglomerati cellulari di scavenger dei radicali liberi. Riportata la capacità di impedire l′apoptosi nelle cellule neuronali ma di indurla nelle cellule muscolari lisce. Inibisce la replicazione dell′HIV. Può servire come substrato per la glutatione transferasi microsomiale.
Note legali
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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