V900394

5-Fluorouracil

Vetec^™, reagent grade, ≥99%

• Sinonimo/i: 2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
• Formula empirica (notazione di Hill): C₄H₃FN₂O₂
• Numero CAS: 51-21-8
• Peso molecolare: 130.08
• Beilstein: 127172
• Numero CE: 200-085-6
• Numero MDL: MFCD00006018
• Codice UNSPSC: 12171500
• ID PubChem: 329829803

Proprietà

• Grado: reagent grade
• Nome Commerciale: Vetec^™
• Saggio: ≥99%
• Stato: powder
• Punto di fusione: 282-286 °C (dec.) (lit.)
• Solubilità: 1 M NH4OH: 50 mg/mL, clear, colorless to faintly yellow
• applicazioni: diagnostic assay manufacturing; hematology; histology
• Temperatura di conservazione: room temp
• Stringa SMILE: FC1=CNC(=O)NC1=O
• InChI: 1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9); GHASVSINZRGABV-UHFFFAOYSA-N
• Informazioni sul gene: human ... TYMS(7298)

Descrizione

Applicazioni

5-Fluorouracil (5-FU) can be used as a precursor for the preparation of 5-FU derivatives such as 1-acyloxyalkyl-5-fluorouracil, 3-acyloxyalkyl-5-fluorouracil, 1, 3-bis (acyloxyalkyl)-5-fluorouracil, and 1-hexylcarbamoyl-5-fluorouracil (HCFU), as potent antitumor agents. It can be also used in the synthesis of 5-5FU/diazeniumdiolate conjugate, which exhibits a greater cytotoxic effect than fluorouracil on cancer cells.

Azioni biochim/fisiol

5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

Note legali

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H351
• Consigli di prudenza: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 3 Oral - Carc. 2
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3