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1612700

USP

Simvastatin

United States Pharmacopeia (USP) Reference Standard

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About This Item

Formula empirica (notazione di Hill):
C25H38O5
Numero CAS:
79902-63-9
Peso molecolare:
418.57
Numero MDL:
MFCD00072007
Codice UNSPSC:
41116107
ID PubChem:
329751099
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

simvastatin

Produttore/marchio commerciale

USP

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

127-132 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC

InChI

1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
RYMZZMVNJRMUDD-HGQWONQESA-N

Informazioni sul gene

human ... HMGCR(3156)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Simvastatin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Simvastatin Tablets

Azioni biochim/fisiol

Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. It is a synthetic analog of lovastatin (Cat. No. M2147).

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H361d

Classi di pericolo

Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Lovastatin United States Pharmacopeia (USP) Reference Standard

USP

1370600

Lovastatin

vibrant-m

Y0002051

Simvastatin impurity K

Simvastatin, Sodium Salt InSolution, ≥95%

Sigma-Aldrich

567022

Simvastatin, Sodium Salt

Tazarotene ≥98% (HPLC)

Sigma-Aldrich

T7080

Tazarotene

Pravastatin sodium salt hydrate ≥98% (HPLC), powder

Sigma-Aldrich

P4498

Pravastatin sodium salt hydrate

Spironolactone United States Pharmacopeia (USP) Reference Standard

USP

1619006

Spironolactone

(±)-Mevalonic acid 5-phosphate lithium salt hydrate 95% (TLC)

Sigma-Aldrich

79849

(±)-Mevalonic acid 5-phosphate lithium salt hydrate

Pitavastatin calcium ≥98% (HPLC)

Sigma-Aldrich

SML2473

Pitavastatin calcium

A Marot et al.
Acta clinica Belgica, 66(2), 134-136 (2011-06-03)
Myopathy, including rhabdomyolysis, is a well-known, albeit rare complication of statin therapy. Predisposing factors include comorbidities and the concomitant use of cytochrome P-450 (CYP) 3A4 inhibitors. We report a case of severe simvastatin-induced rhabdomyolysis triggered by the addition of amiodarone
L B Ramsey et al.
Clinical pharmacology and therapeutics, 96(4), 423-428 (2014-06-12)
Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association
Gerard J Criner et al.
The New England journal of medicine, 370(23), 2201-2210 (2014-05-20)
Retrospective studies have shown that statins decrease the rate and severity of exacerbations, the rate of hospitalization, and mortality in chronic obstructive pulmonary disease (COPD). We prospectively studied the efficacy of simvastatin in preventing exacerbations in a large, multicenter, randomized
Stephen J Nicholls et al.
The American journal of cardiology, 105(1), 69-76 (2010-01-28)
Statins are the most commonly prescribed agents for lowering levels of low-density lipoprotein (LDL) cholesterol. Although dose-dependent reductions in levels of atherogenic lipids are observed with all statins, the impact of increasing dose has not been fully elucidated. An individual
Daniel F McAuley et al.
The New England journal of medicine, 371(18), 1695-1703 (2014-10-01)
Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with simvastatin would improve clinical
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