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Key Documents

1019701

USP

Amiloride hydrochloride

United States Pharmacopeia (USP) Reference Standard

Sinonimo/i:

Amiloride hydrochloride dihydrate, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate

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About This Item

Formula empirica (notazione di Hill):
C6H8ClN7O · HCl · 2H2O
Numero CAS:
17440-83-4
Peso molecolare:
302.12
Codice UNSPSC:
41116107
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

amiloride

Produttore/marchio commerciale

USP

applicazioni

pharmaceutical (small molecule)

Formato

neat

InChI

1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
LTKVFMLMEYCWMK-UHFFFAOYSA-N

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Descrizione generale

Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.

Applicazioni

Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amiloride Hydrochloride and Hydrochlorothiazide Tablets
  • Amiloride Hydrochloride Tablets

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Hong Wang et al.
Hypertension (Dallas, Tex. : 1979), 62(4), 738-745 (2013-08-21)
In Dahl salt-sensitive rats (Dahl SS), glomerular capillary pressure increases in response to high salt intake and this is accompanied by significant glomerular injury compared with spontaneously hypertensive rats with similar blood pressure. Glomerular capillary pressure is controlled mainly by
Yusuke Ito et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(5), R315-R327 (2014-01-10)
Zebrafish Na(+)/H(+) exchanger 3b (zNHE3b) is highly expressed in the apical membrane of ionocytes where Na(+) is absorbed from ion-poor fresh water against a concentration gradient. Much in vivo data indicated that zNHE3b is involved in Na(+) absorption but not
Anne P Sinke et al.
American journal of physiology. Renal physiology, 306(5), F525-F533 (2013-12-20)
Lithium is the most common cause of nephrogenic diabetes insipidus (Li-NDI). Hydrochlorothiazide (HCTZ) combined with amiloride is the mainstay treatment in Li-NDI. The paradoxical antidiuretic action of HCTZ in Li-NDI is generally attributed to increased sodium and water uptake in
Shujie Shi et al.
American journal of physiology. Renal physiology, 305(11), F1585-F1592 (2013-10-11)
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits
Juraj Rievaj et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(4), G303-G313 (2013-06-15)
Intestinal calcium (Ca²⁺) absorption occurs via paracellular and transcellular pathways. Although the transcellular route has been extensively studied, mechanisms mediating paracellular absorption are largely unexplored. Unlike passive diffusion, secondarily active paracellular Ca²⁺ uptake occurs against an electrochemical gradient with water
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