D7693

Dynasore

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

• Sinonimo/i: 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide
• Formula empirica (notazione di Hill): C₁₈H₁₄N₂O₄ · xH₂O
• Numero CAS: 1202867-00-2
• Peso molecolare: 322.31 (anhydrous basis)
• Numero MDL: MFCD11045288
• Codice UNSPSC: 12352200
• ID PubChem: 329798784
• NACRES: NA.77

Proprietà

• product name: Dynasore,
• Forma fisica: powder
• Livello qualitativo: 100
• Condizioni di stoccaggio: protect from light
• Colore: off-white
• Solubilità: DMSO: ≥10 mg/mL; H₂O: insoluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
• InChI: 1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;; FKWZHQSDBMSHTN-ZIOFAICLSA-N

Descrizione

Descrizione generale

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.

Applicazioni

Dynasore hydrate has been used:

• for priming fetal mesenchymal stem/stromal cells (fMSC)
• in confocal microscopy
• in wound healing/scratch and tube-formation assay
• to analyse its effects on Coxsackievirus A9 (CAV9) infection
• to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
• in live imaging of cells

Azioni biochim/fisiol

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informazioni sulla sicurezza

• Pittogrammi: GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H400
• Consigli di prudenza: P273
• Classi di pericolo: Aquatic Acute 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves