129876

Amiloride, Hydrochloride

An inhibitor of angiogenesis.

• Sinonimo/i: Amiloride, Hydrochloride, Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
• Formula empirica (notazione di Hill): C₆H₈ClN₇O · xHCl
• Numero CAS: 2016-88-8
• Peso molecolare: 229.63 (free base basis)
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic); protect from light
• Colore: off-white to yellow
• Solubilità: water: 2.5 mg/mL; DMSO: 5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 10-30°C
• InChI: 1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H; ACHKKGDWZVCSNH-UHFFFAOYSA-N

Descrizione

Descrizione generale

An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na⁺/H⁺ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.

An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na⁺ entry and Na⁺,K⁺-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
capillary morphogenesis

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 130 µM inhibiting capillary morphogenesis completely and reversibly

Attenzione

Toxicity: Toxic (F)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Knoll, A., et al. 1999. Microvasc. Res.58, 1.
Swiercz, R., et al. 1999. Oncol. Rep.6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable