PHL89811

Triptolide

phyproof^® Reference Substance

• Sinonimo/i: PG 490
• Formula empirica (notazione di Hill): C₂₀H₂₄O₆
• Numero CAS: 38748-32-2
• Peso molecolare: 360.40
• Numero MDL: MFCD00210565
• Codice UNSPSC: 41116107
• NACRES: NA.24

Proprietà

• Grado: primary reference standard
• Nome Commerciale: phyproof^® Reference Substance
• Saggio: ≥98.0% (HPLC)
• Produttore/marchio commerciale: PhytoLab
• applicazioni: food and beverages
• Formato: neat
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]
• InChI: 1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1; DFBIRQPKNDILPW-KTGKZQHOSA-N

Descrizione

Descrizione generale

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Azioni biochim/fisiol

Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNF_α) induction of apoptosis in part through the suppression of c-IAP₂ and c-IAP₁ induction.

Note legali

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H330,H361f
• Consigli di prudenza: P201 - P301 + P310 + P330 - P304 + P340 + P310
• Classi di pericolo: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable