Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

C0869

Sigma-Aldrich

Celastrol

≥98% (HPLC), solid, antioxidant

Sinonimo/i:

10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C29H38O4
Numero CAS:
34157-83-0
Peso molecolare:
450.61
Numero MDL:
MFCD03424073
Codice UNSPSC:
12352200
ID PubChem:
329774823
NACRES:
NA.77

product name

Celastrol, ≥98% (HPLC), solid

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

red

Solubilità

DMSO: >10 mg/mL
H2O: insoluble

Temperatura di conservazione

−20°C

Stringa SMILE

CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(O)=O

InChI

1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
KQJSQWZMSAGSHN-JJWQIEBTSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Applicazioni

Celastrol has been:
  • used intraperitoneally to inject into experimental mice to study its role in nonalcoholic fatty liver disease (NAFLD)
  • used in culture medium to study its effect on lipopolysaccharide-induced inflammatory injury in human keratinocyte cell culture
  • used to study its effect in vitro and in vivo in VCaP cells

Azioni biochim/fisiol

Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).
Celastrol is a quinone methide triterpene naturally present in Tripterygium wilfordii. It is useful in treating rheumatoid arthritis. Celastrol prevents the action of proteasome and nuclear factor Κb.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 7

1 of 7

Triptolide phyproof® Reference Substance

PHL89811

Triptolide

Withaferin A ≥95% (HPLC)

Sigma-Aldrich

W4394

Withaferin A

R,S-Gambogic acid phyproof® Reference Substance

PHL80455

R,S-Gambogic acid

Rhynchophylline ≥95% (HPLC)

Sigma-Aldrich

SML2345

Rhynchophylline

Andrographolide 98%

Sigma-Aldrich

365645

Andrographolide

Violacein from Janthinobacterium lividum >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)

Sigma-Aldrich

V9389

Violacein from Janthinobacterium lividum

Probucol analytical standard

Supelco

P9672

Probucol

A C Allison et al.
Progress in neuro-psychopharmacology & biological psychiatry, 25(7), 1341-1357 (2001-08-22)
In the brains of patients with Alzheimer's disease (AD) signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes
Radhamani Kannaiyan et al.
Cancer letters, 303(1), 9-20 (2010-12-21)
Identification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology. Celastrol is one such compound that was originally identified from traditional Chinese medicine (Thunder of God Vine) almost three decades ago and
A Mariño-Enríquez et al.
Oncogene, 33(14), 1872-1876 (2013-04-16)
Most gastrointestinal stromal tumors (GISTs) contain KIT or PDGFRA kinase gain-of-function mutations, and therefore respond clinically to imatinib and other tyrosine kinase inhibitor (TKI) therapies. However, clinical progression subsequently results from selection of TKI-resistant clones, typically containing secondary mutations in
Mengfei Liu et al.
Nature communications, 12(1), 4560-4560 (2021-07-29)
Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression. Super-enhancers are expansive regulatory elements driving augmented gene expression. Here, we explore the mechanistic role of super-enhancers linking cytokine TNFα with chemokine
Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cells
Xiong Y, et al.
Biomedicine and Pharmacotherapy, 105, 798-804 (2018)
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.