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V2764

Sigma-Aldrich

Anti-Vanilloid Receptor-1 antibody produced in rabbit

enhanced validation

IgG fraction of antiserum, buffered aqueous solution

Sinonimo/i:

Anti-TRPV1, Anti-VR-1

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About This Item

Numero MDL:
MFCD02686673
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

IgG fraction of antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 90 kDa

Reattività contro le specie

rat

Convalida avanzata

recombinant expression
Learn more about Antibody Enhanced Validation

tecniche

microarray: suitable
western blot: 1:1,000 using whole cell extract of 293T cells expressing rat VR-1

N° accesso UniProt

O35433

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... TRPV1(7442)

Categorie correlate

Descrizione generale

Vanilloid Receptor-1 (VR-1) is a cation channel protein that stimulates a burning pain sensation upon binding to capsaicin, a component of ′hot′ chilli peppers. VR-1 is also activated by noxious heat stimuli. Moreover, VR-1 can combine both, heat and chemical stimuli to cause a sensation of pain in vivo.

Specificità

Anti-Vanilloid Receptor-1 antibody is specific for vanilloid receptor-1 (90 kDa) in rats. The vanilloid receptor-1 immunizing peptide (rat, amino acids 817-838) specifically inhibits the staining of the vanilloid receptor-1 band in immunoblotting.

Immunogeno

synthetic peptide corresponding to the C-terminus of rat vanilloid receptor-1 (amino acids 817-838) conjugated to KLH. The sequence is highly conserved in guinea pig (~85% identity) and human (~70% identity) and is not found in rat VRL-1.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Vascular Expression of Transient Receptor Potential Vanilloid 1 (TRPV1).
Claire A Sand et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 63(6), 449-453 (2015-03-27)
M Tominaga et al.
Neuron, 21(3), 531-543 (1998-10-13)
Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (VR1) is a cation channel that is also activated by noxious heat. Here, analysis of
Elvira Varela-López et al.
Oxidative medicine and cellular longevity, 2021, 8531975-8531975 (2021-08-17)
The potential transient vanilloid receptor type 1 (TRPV1) plays important functional roles in the vascular system. In the present study, we explored the role of the TRPV1 in the production of nitric oxide (NO), biopterines (BH4 and BH2), cyclic guanosine
M J Caterina et al.
Nature, 389(6653), 816-824 (1997-12-31)
Capsaicin, the main pungent ingredient in 'hot' chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. We have used an expression cloning strategy based on
Juan Carlos Torres-Narváez et al.
International journal of environmental research and public health, 16(19) (2019-09-29)
The purpose of the present study was to analyze the actions of transient receptor potential vanilloid type 1 (TRPV1) agonist capsaicin (CS) and of its antagonist capsazepine (CZ), on cardiac function as well as endothelial biomarkers and some parameters related
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