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U6508

Sigma-Aldrich

UCN-01

≥97% (HPLC), powder

Sinonimo/i:

KW-2401

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About This Item

Formula empirica (notazione di Hill):
C28H26N4O4
Numero CAS:
112953-11-4
Peso molecolare:
482.53
Numero MDL:
MFCD26960886
Codice UNSPSC:
12352200
ID PubChem:
24724639
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥97% (HPLC)

Forma fisica

powder

Attività ottica

[α]20/D 130 to 160°, c = 0.2 in DMSO

Condizioni di stoccaggio

protect from light

Colore

light yellow

Solubilità

DMSO: >5 mg/mL
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

[H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8

InChI

1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
PBCZSGKMGDDXIJ-HQCWYSJUSA-N

Informazioni sul gene

human ... CDK2(1017) , CDK4(1019) , CDK6(1021) , CHEK1(1111) , PDPK1(5170) , PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584) , PRKCQ(5588) , PRKCZ(5590) , PRKD1(5587) , PRKD3(23683)

Applicazioni

UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.

Azioni biochim/fisiol

UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.

Caratteristiche e vantaggi

This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Motofumi Suzuki et al.
Translational oncology, 10(4), 491-500 (2017-05-28)
Checkpoint kinase 1 (Chk1) is an evolutionarily conserved serine/threonine kinase that plays an important role in G
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Science advances, 4(8), eaat4985-eaat4985 (2018-08-14)
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UCN-01 (7-hydroxystaurosporine) is a protein kinase inhibitor which is under development as an anti-cancer agent in the USA and Japan. Although UCN-01 was originally isolated from the culture broth of Streptomyces sp. as a protein kinase C-selective inhibitor, its ultimate
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