T3573
RANK Ligand/TRANCE human
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Sinonimo/i:
Osteoclast Differentiation Factor (ODF), Osteoprotegerin Ligand (OPGL), Receptor Activator of NF-KB Ligand (RANKL), TNF-related activation-induced cytokines (TRANCE)
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in NSO cells
Saggio
>90% (SDS-PAGE)
Stato
lyophilized powder
Potenza
1.5-7.5 ng/mL ED50
PM
glycolysylated recombinant product ~35 kDa by SDS-PAGE
calculated mol wt 23 kDa
Confezionamento
pkg of 10 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
Impurezze
endotoxin, tested
N° accesso UniProt
applicazioni
cell analysis
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... TNFSF11(8600)
Descrizione generale
Tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11) is also known as receptor activator of nuclear factor-κB ligand (RANKL). It is a type II transmembrane signaling receptor. It has a molecular weight of around 35kDa. This protein contains an amino-terminal intracellular tail and a carboxy-terminal extracellular region, that bears a connecting stalk and a receptor-binding domain. Tnfsf11 is located on human chromosome 13q14.11.
Applicazioni
RANK Ligand/TRANCE human can be used in in vitro osteoclastogenic assays for osteoclast differentiation.
RANK Ligand/TRANCE human has been used to stimulate differentiation.
Azioni biochim/fisiol
RANK Ligand (receptor activator of NF-kB ligand (RANKL) also referred to as TNF-related activation induced cytokines (TRANCE) or osteoprotegerin ligand is a protein that belongs to tumor necrosis factor (TNF) family. It stimulates the mature dendritic cells and induces the cytokine production. RANKL also facilitates bone remodelling and possess an angiogenic activity.
RANK Ligand/TRANCE, a member of the TNF superfamily, induces activation of the c-jun N-terminal kinase, enhances T-cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis. Mouse and human RANK Ligand share 85% amino acid identity. RANK is the cell surface receptor for RANK Ligand.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS and 500 mM NaCl, pH 6.5, with 50 μg BSA per 1 μg as a carrier protein.
Risultati analitici
The biological activity is measured by its ability to induce osteoclast differentiation on mouse splenocytes.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor
Nelson C A, et al.
Structure, 20(11), 1971-1982 (2012)
Matrine prevents bone loss in ovariectomized mice by inhibiting RANKL-induced osteoclastogenesis
Chen X, et al.
Faseb Journal, 31(11), 4855-4865 (2017)
Jeong-Ki Min et al.
The Journal of biological chemistry, 278(41), 39548-39557 (2003-08-02)
Vascular endothelial growth factor (VEGF) is known as a key regulator of angiogenesis during endochondral bone formation. Recently, we demonstrated that TNF-related activation-induced cytokine (TRANCE or RANKL), which is essential for bone remodeling, also had an angiogenic activity. Here we
Cytosolic phospholipase A2 and eicosanoids modulate life, death and function of human osteoclasts in vitro
Allard-Chamard H, et al.
Prostaglandins, Leukotrienes, and Essential Fatty Acids, 90(4), 117-123 (2014)
R Josien et al.
Journal of immunology (Baltimore, Md. : 1950), 162(5), 2562-2568 (1999-03-11)
TNF-related activation-induced cytokine (TRANCE) is a member of the TNF family recently identified in activated T cells. We report here that TRANCE mRNA is constitutively expressed in memory, but not naive, T cells and in single-positive thymocytes. Upon TCR/CD3 stimulation
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.