TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
Sinonimi:
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Specie:
Human TNFSF11 (8600), Mouse Tnfsf11 (21943), Rat Tnfsf11 (117516), Zebrafish tnfsf11 (100331628), dog TNFSF11 (609418), chicken TNFSF11 (428067), naked mole-rat Tnfsf11 (101696350), domestic guinea pig Tnfsf11 (100713226), cow TNFSF11 (513836)
ID UniProtKB:
ID gene:
- Human(8600) Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
- Mouse(21943) tumor necrosis factor (ligand) superfamily, member 11
- Rat(117516) tumor necrosis factor (ligand) superfamily, member 11
- Zebrafish(100331628) tumor necrosis factor (ligand) superfamily, member 11
- dog(609418) tumor necrosis factor (ligand) superfamily, member 11
- chicken(428067) tumor necrosis factor (ligand) superfamily, member 11
- naked mole-rat(101696350) tumor necrosis factor (ligand) superfamily, member 11
- domestic guinea pig(100713226) tumor necrosis factor (ligand) superfamily, member 11
- cow(513836) tumor necrosis factor (ligand) superfamily, member 11
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-RANKL Antibody, clone 6A12.1, clone 6A12.1, from mouse,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-RANKL/TNFSF11 Antibody, clone 1H17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
bovine, human, monkey, porcine
Applicazione
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TNFSF11 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse
Applicazione
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-TNFSF11 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
western blot
Proteins
N° Catalogo
Descrizione
Specie
RANK Ligand from mouse, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture,
Specie
mouse
sRANKL human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Specie
human
RANK Ligand/TRANCE human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Specie
human
Proteina sRANKL (Soluble RANK Ligand), umana ricombinante, The recombinant human sRANKL protein is produced in E. Coli.,
Specie
human
sRank Ligand from rat, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Specie
rat
esiRNA
N° Catalogo
Descrizione
Specie