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T2528

Sigma-Aldrich

Terbutaline hemisulfate salt

Sinonimo/i:

2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt

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About This Item

Formula condensata:
C12H19NO3 · 1/2H2SO4
Numero CAS:
23031-32-5
Peso molecolare:
274.32
Numero CE:
245-386-3
Numero MDL:
MFCD00079584
Codice UNSPSC:
12352200
ID PubChem:
24278729
NACRES:
NA.77

Livello qualitativo

100

Solubilità

H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

Ideatore

Novartis

Stringa SMILE

OS(O)(=O)=O.CC(C)(C)NCC(O)c1cc(O)cc(O)c1.CC(C)(C)NCC(O)c2cc(O)cc(O)c2

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
KFVSLSTULZVNPG-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRB1(153) , ADRB2(154) , ADRB3(155)

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Applicazioni

Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat4. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs5.

Azioni biochim/fisiol

Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.

Caratteristiche e vantaggi

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota sulla preparazione

Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.

Applicazioni

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H361,H370

Classi di pericolo

Repr. 2 - STOT SE 1

Organi bersaglio

Cardio-vascular system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCCC7481
BCBV3715
BCBQ7406V
BCBQ7406
MKBS1964V

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J Elers et al.
International journal of sports medicine, 33(12), 1026-1033 (2012-07-12)
We examined urine and serum concentrations after therapeutic use of single and repetitive doses of inhaled and supratherapeutic oral use of terbutaline. We compared the concentrations in 10 asthmatics and 10 healthy subjects in an open-label, cross-over study with 2
Andrew H Travers et al.
The Cochrane database of systematic reviews, 12, CD010179-CD010179 (2012-12-14)
Inhaled beta-agonist therapy is central to the management of acute asthma. This review evaluates the benefit of an additional use of intravenous beta(2)-agonist agents. To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma
K Törneke et al.
Journal of veterinary pharmacology and therapeutics, 21(5), 388-392 (1998-11-12)
Beta2-adrenoceptor agonists are used as bronchodilators in both humans and horses. Of these drugs, clenbuterol is the one most frequently used when treating chronic obstructive pulmonary disease in the horse, while salbutamol and terbutaline are used in the treatment of
Md Faiyazuddin et al.
International journal of pharmaceutics, 434(1-2), 59-69 (2012-05-16)
Terbutaline submicron particles (SμTBS) were prepared by nanoprecipitation technique followed by spray drying for deep lungs deposition. Inhalable SμTBS particles were 645.16 nm of diameter with 0.11μm of MMAD, suggested for better aerosol effects. Both submicron and micron-sized TBS particles
Anthony M J Sanchez et al.
European journal of applied physiology, 113(2), 411-418 (2012-07-07)
This study aimed to investigate the effects on a possible improvement in aerobic and anaerobic performance of oral terbutaline (TER) at a supra-therapeutic dose in 7 healthy competitive male athletes. On day 1, ventilatory threshold, maximum oxygen uptake [Formula: see
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Chromatograms

application for HPLC

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