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T0557

Sigma-Aldrich

Taurodesossicolato di sodio

BioXtra, ≥97% (TLC)

Sinonimo/i:

Acido 2-([3α,12α-diidrossi-24-osso-5β-colan-24-il]amino)etanesolfonico, Acido taurodesossicolico

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About This Item

Formula condensata:
C26H44NO6SNa · xH2O
Numero CAS:
207737-97-1
Peso molecolare:
521.69 (anhydrous basis)
Beilstein:
3901204
Numero MDL:
MFCD00149238
Codice UNSPSC:
12161900
ID PubChem:
24899897
NACRES:
NA.25

Descrizione

anionic

Livello qualitativo

200

Nome Commerciale

BioXtra

Saggio

≥97% (TLC)

PM

micellar avg mol wt 3100

Numero d'aggregazione

6

Impurezze

≤0.002% Phosphorus (P)
≤0.1% Insoluble matter

CMC

1-4 mM (20-25°C)

Solubilità

H2O: 0.5 M, clear, colorless to faintly yellow

Anioni in tracce

chloride (Cl-): ≤0.5%
sulfate (SO42-): ≤0.05%

Cationi in tracce

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.01%
Mg: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

Stringa SMILE

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C26H45NO6S.Na.H2O/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;;/m1../s1
OLPIZAYYAVQETM-GGPRKOIFSA-M

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Descrizione generale

Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.

Applicazioni

Sodium tauroursodeoxycholate has been used in a study to assess short-term feedback regulation of bile salt uptake in rodent liver. It has also been used in a study to investigate its potential to resolve endoplasmic reticulum (ER) stress in intestinal epithelial cells. It is also used for isolation of membrane proteins including inner mitochondrial membrane proteins.
Detergente anionico correlato ai sali biliari usato per isolare le proteine di membrana incluse quelle della membrana mitocondriale interna.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Emanuel Berger et al.
Biochemical and biophysical research communications, 409(4), 610-615 (2011-05-25)
Inflammatory bowel diseases (IBD) are chronically relapsing and immune-mediated disorders of the gastrointestinal tract. Endoplasmic reticulum (ER) stress mechanisms in the epithelium have been demonstrated to be implemented into the pathogenesis of intestinal inflammation. Chemical chaperones have been demonstrated to
Stefanie Mühlfeld et al.
Hepatology (Baltimore, Md.), 56(6), 2387-2397 (2012-07-19)
The sodium taurocholate cotransporting polypeptide (Ntcp) is the major bile salt uptake transporter at the sinusoidal membrane of hepatocytes. Short-term feedback regulation of Ntcp by primary bile salts has not yet been investigated in vivo. Subcellular localization of Ntcp was
Kalinne Kelly Lima Gadelha et al.
Experimental physiology, 104(2), 199-208 (2018-12-19)
What is the central question of this study? Is the responsiveness of isolated segments of the rat oesophagus to contractile or relaxant stimuli susceptible to acute luminal exposure of the oesophagus to an acid solution that contains pepsin and bile
Salma Alavi et al.
Cell, 181(7), 1533-1546 (2020-07-08)
The gut microbiome is the resident microbial community of the gastrointestinal tract. This community is highly diverse, but how microbial diversity confers resistance or susceptibility to intestinal pathogens is poorly understood. Using transplantation of human microbiomes into several animal models
Susanne Naumann et al.
Nutrients, 11(6) (2019-06-28)
Dietary fibres are reported to interact with bile acids, preventing their reabsorption and promoting their excretion into the colon. We used a method based on in vitro digestion, dialysis, and kinetic analysis to investigate how dietary fibre enriched food ingredients
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