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T4009

Sigma-Aldrich

Taurocholic acid sodium salt hydrate

≥95% (HPLC)

Sinonimo/i:

2-[(3α,7α,12α-Trihydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid, 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Sodium taurocholate hydrate

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About This Item

Formula empirica (notazione di Hill):
C26H44NNaO7S · xH2O
Numero CAS:
345909-26-4
Peso molecolare:
537.68 (anhydrous basis)
Numero CE:
205-653-7
Numero MDL:
MFCD00150819
Codice UNSPSC:
12161900
ID PubChem:
24900186
NACRES:
NA.25

Origine biologica

synthetic (organic)

Livello qualitativo

200

Descrizione

anionic

Saggio

≥95% (HPLC)

Forma fisica

powder

PM

micellar avg mol wt 2100

Numero d'aggregazione

4

CMC

3-11 mM (20-25°C)

Gruppo funzionale

sulfonic acid

Condizioni di spedizione

ambient

Temperatura di conservazione

room temp

Stringa SMILE

[Na+].[H]O[H].[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@H](CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCS([O-])(=O)=O

InChI

1S/C26H45NO7S.Na.H2O/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;;/m1../s1
RDAJAQDLEFHVNR-NEMAEHQESA-M

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Descrizione generale

Taurocholic acid sodium salt hydrate is a bile acid with detergent capabilities.

Applicazioni

Taurocholic acid sodium salt hydrate has been used in a study to assess the adsorption of bile acids and salts to vegetable fibrous tissue. It has also been used in a study to investigate a method for determination of conjugated and unconjugated bile salts in serum and jejunal fluid.
Anionic detergent used for protein solubilization.

Azioni biochim/fisiol

Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na(+)/taurocholate cotransporter (NTCP) and MRP3 into the hepatic carnalicular.

Nota sulla preparazione

Synthesized from cholic acid

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sigma-Aldrich

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Cholic acid from bovine and/or ovine, ≥98%

Sigma-Aldrich

C1129

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Bile acids, conjugated

Sigma-Aldrich

CBA

Bile acids, conjugated

Sodium taurolithocholate

Sigma-Aldrich

T7515

Sodium taurolithocholate

Chenodeoxycholic acid

Sigma-Aldrich

C9377

Chenodeoxycholic acid

Taurocholic Acid, Sodium Salt ULTROL® Grade, ≥98% (TLC), detergent to solubilize membrane-bound proteins in their native state

Millipore

580218

Taurocholic Acid, Sodium Salt

Joseph J Orsini et al.
Clinica chimica acta; international journal of clinical chemistry, 413(15-16), 1270-1273 (2012-05-03)
We sought to modify a previously published tandem mass spectrometry method of screening for 5 lysosomal storage disorders (LSDs) in order to make it better suited for high-throughput newborn screening. Two 3-mm dried blood spot (DBS) punches were incubated, each
Studies on the adsorption of bile salts to non-absorbed components of diet.
M A Eastwood et al.
Biochimica et biophysica acta, 152(1), 165-173 (1968-01-10)
A Tangerman et al.
Clinica chimica acta; international journal of clinical chemistry, 159(2), 123-132 (1986-09-15)
A reliable method is described for the determination of conjugated and unconjugated bile acids in serum and jejunal fluid. Bile acids are extracted using reverse-phase octadecylsilane bonded silica cartridges and are separated into their unconjugated and conjugated fractions using the
Theresa D Ho et al.
Infection and immunity, 82(6), 2345-2355 (2014-03-26)
Clostridium difficile is a clinically important pathogen and the most common cause of hospital-acquired infectious diarrhea. Expression of the C. difficile gene csfV, which encodes σ(V), an extracytoplasmic function σ factor, is induced by lysozyme, which damages the peptidoglycan of
Studies on the Antibacterial Properties of the Bile Acids and some Compounds Derived from Cholanic Acid
M. Stacey and M. Webb
Proc. Royal Soc. Lond. B., 134, 523-523 (1947)
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Articoli

Probiotics and Human Health

probiotics-and-human

Protocolli

Fast and Robust HPLC Separation of Bile Acids and Conjugates with Ascentis Express C18

This method is particularly useful in research into the role of individual bile acids as signaling molecules; suitable for clinical laboratories to investigate potential mechanisms linked to gut hormone profiles and glycemic control.

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