SRP4596
IFN-alpha 1 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinonimo/i:
IFN-α 1, IFNA1, Interferon-α
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About This Item
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥95% (HPLC)
≥95% (SDS-PAGE)
Forma fisica
lyophilized
Potenza
1x10^8 units/mg
PM
~19.3 kDa
Confezionamento
pkg of 100 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
Impurezze
endotoxin, tested
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... IFNA1(3439)
Descrizione generale
IFN-α1 (interferon α 1) is a type 1 interferon. Human IFN-a1 is a 19.3kDa protein containing 166 amino acid residues. IFN-α1 belongs to the type I interferon (IFN) family and is present in leukocytes. The IFN-α1 gene is mapped to human chromosome 9p21.3.
Applicazioni
IFN-alpha 1 human has been used:
- to treat Vero and breast cancer (MDA-MB-231) cells in interferon assay before viral infection
- as a ligand to vaccinia virus B18R protein in analytical size exclusion chromatography
- to treat chikungunya infected human embryonic kidney cell line (HEK293T) to test its effect on Signal transducer and activator of transcription 1 (STAT1) phosphorylation
- as recombinant interferon to treat lung fibroblast cell line (IMR90) to monitor histone chaperone (HIRA) response
Azioni biochim/fisiol
IFN-α1 (interferon α 1) is a lymphoid factor that possesses potent anti-viral activity. IFN-α1 interacts with IFNAR1 (interferon α receptor 1) and IFNAR2. The interaction activates JAK1 (janus-activated kinase 1) and tyrosine kinase 2. These events phosphorylate and activate STAT1 and STAT2 (signal transducer and activator of transcription proteins), leading to the upregulation of interferon-stimulated genes some of which encode antiviral proteins. IFN-alpha 1 (IFN-α1) mediates apoptosis in specific tissues. It may be useful in treating laryngeal carcinoma. The interaction of microRNA, miR-181b with IFN-α1, is regarded as a risk factor in systemic lupus erythematosus.
Stato fisico
Lyophilized without any additives.
Ricostituzione
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1 mg/mL. This solution can then be diluted into other aqueous buffers.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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