SRP3080
IL-17 human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Sinonimo/i:
CTLA-8, IL-17
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥98% (HPLC)
≥98% (SDS-PAGE)
Stato
lyophilized
PM
31.0 kDa
Confezionamento
pkg of 25 μg
tecniche
cell culture | mammalian: suitable
Impurezze
<0.1 EU/μg endotoxin, tested
Colore
off-white to yellow
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... IL17A(3605)
Descrizione generale
The gene IL17A (interleukin 17A), also referred to as IL-17, is mapped to human chromosome 6p12.2. The gene contain three exons and encodes a proinflammatory cytokine produced by activated T cells.
Azioni biochim/fisiol
The cytokine interleukin 17A is involved in the activation of proinflammatory cytokines, chemokines, and cell adhesion molecules in several cell types such as, macrophages, dendritic cells, T cells, synovial cells, and endothelial cells. Overexpression of this protein has been associated with rheumatoid arthritis, systemic lupus erythematosus, Behcet′s disease, allograft rejection, nephritic syndrome, asthma, and multiple sclerosis. In mice, it has been observed to be implicated in the development of allergic and autoimmune diseases. Polymorphism in IL17A gene has been associated with lung cancer.
Sequenza
MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
Stato fisico
Lyophilized with no additives.
Ricostituzione
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
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Journal of Immunology, 177, 566-573 (2006)
Interleukin-17A and -17F genes polymorphisms in lung cancer.
Kaabachi W
Cytokine, 66, 23-29 (2014)
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Proceedings of the National Academy of Sciences of the United States of America, 111(33), E3422-E3431 (2014-08-06)
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American journal of respiratory cell and molecular biology, 50(6), 1053-1063 (2014-01-08)
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Junhua Wang et al.
PLoS neglected tropical diseases, 9(5), e0003755-e0003755 (2015-05-09)
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