SML3596

Losmapimod

≥98% (HPLC)

• Sinonimo/i: 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)nicotinamide, 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide, 6-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide, CID 11552706, GSK-AHAB, GW856553X, SB 856553
• Formula empirica (notazione di Hill): C₂₂H₂₆FN₃O₂
• Numero CAS: 585543-15-3
• Peso molecolare: 383.46
• Numero MDL: MFCD16619322
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(NCC(C)(C)C)C1=CC=C(C2=C(C)C(F)=CC(C(NC3CC3)=O)=C2)N=C1
• InChI: 1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28); KKYABQBFGDZVNQ-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Losmapimod is a potent and selective inhibitor of the p38 mitogen-activated protein kinases (MAPK) family. In SHR-SP rats losmapimod improves survival, endothelial-dependent and -independent vascular relaxation. Also losmapimod attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1 (IL-1 ). Losmapimod produces antidepressant and antipsychotic effects.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable