D3897

2′-Deoxycytidine

≥99% (HPLC)

• Sinonimo/i: Cytosine deoxyriboside
• Formula empirica (notazione di Hill): C₉H₁₃N₃O₄
• Numero CAS: 951-77-9
• Peso molecolare: 227.22
• Beilstein: 87567
• Numero CE: 213-454-1
• Numero MDL: MFCD00006547
• Codice UNSPSC: 41106305
• ID PubChem: 24893793
• NACRES: NA.51

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Saggio: ≥99% (HPLC)
• Forma fisica: powder
• Solubilità: water: 50 mg/mL, clear, colorless to very faintly yellow
• Temperatura di conservazione: −20°C
• Stringa SMILE: NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2
• InChI: 1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1; CKTSBUTUHBMZGZ-SHYZEUOFSA-N

Descrizione

Descrizione generale

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

Applicazioni

2′-Deoxycytidine has been used:

• as a substrate for Trypanosoma brucei cytidine deaminase (TbCDA) to measure its activity
• as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
• to study the role of autophagy in response to oncogenes and DNA replication stress

Azioni biochim/fisiol

2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)