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89270

Sigma-Aldrich

Timidina

≥99.0% (HPLC)

Sinonimo/i:

1-(2-deossi-β-D-ribofuranosil)-5-metiluracile, 1-(2-deossi-β-D-ribofuranosil)timina, 2′-deossitimidina, Timina deossiriboside, dT

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About This Item

Formula empirica (notazione di Hill):
C10H14N2O5
Numero CAS:
50-89-5
Peso molecolare:
242.23
Beilstein:
89285
Numero CE:
200-070-4
Numero MDL:
MFCD00006537
Codice UNSPSC:
41106305
ID PubChem:
329769717
NACRES:
NA.51

Origine biologica

synthetic

Saggio

≥99.0% (HPLC)

Stato

powder

Attività ottica

[α]20/D +19±1°, c = 1% in H2O

Punto di fusione

185-190 °C
186-188 °C (lit.)

Solubilità

hot water: 1 g/10 mL

Stringa SMILE

CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1
IQFYYKKMVGJFEH-XLPZGREQSA-N

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Applicazioni

Thymidine has been used:
  • to culture human fibroblast cell lines.
  • in in vitro wound healing assay.
  • to culture various cancer cell lines.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
BCCD0663
BCCB6626
BCBX9556
BCBW5971
BCBT9461

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Sigma-Aldrich

G6752

Guanosine

2′-Deoxyguanosine hydrate 99%

Sigma-Aldrich

854999

2′-Deoxyguanosine hydrate

Uridine ≥99%

Sigma-Aldrich

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Uridine

2′-Deoxycytidine hydrochloride BioReagent, suitable for cell culture

Sigma-Aldrich

D0776

2′-Deoxycytidine hydrochloride

5′-Deoxyadenosine methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase substrate

Sigma-Aldrich

D1771

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Cytidine BioReagent, suitable for cell culture, powder, ≥99%

Sigma-Aldrich

C4654

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RO-3306 ≥98% (HPLC)

Sigma-Aldrich

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RO-3306

Cédric F Invernizzi et al.
The Journal of antimicrobial chemotherapy, 68(10), 2192-2196 (2013-06-12)
We recently reported the preferential selection of the K65R resistance mutation in subtype C HIV-1 compared with subtype B and showed the underlying mechanism to be dependent on subtype C-specific silent nucleotide polymorphisms, i.e. genomic mutations that change the genotype
Edward J Gane et al.
Gastroenterology, 146(1), 138-146 (2013-09-27)
There is a close relationship between chronic hepatitis B virus infection and chronic renal disease. We analyzed changes in renal function using different markers of glomerular filtration rate (GFR) in multiple studies of telbivudine treatment of patients with chronic hepatitis
Yee Suan Poo et al.
PLoS neglected tropical diseases, 8(12), e3354-e3354 (2014-12-05)
The recent epidemic of the arthritogenic alphavirus, chikungunya virus (CHIKV) has prompted a quest to understand the correlates of protection against virus and disease in order to inform development of new interventions. Herein we highlight the propensity of CHIKV infections
Anne P Bouvy et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(8), 1587-1597 (2014-04-29)
To evaluate the influence of induction therapy on Tregs we investigated their origin, kinetics and function in kidney transplant patients after treatment with T-cell depleting rabbit antithymocyte globulin (rATG) or IL-2 receptor antagonist basiliximab. Flow cytometry was used to study
Michael V Airola et al.
PloS one, 9(8), e105830-e105830 (2014-08-22)
Acid sphingomyelinase (aSMase) is a human enzyme that catalyzes the hydrolysis of sphingomyelin to generate the bioactive lipid ceramide and phosphocholine. ASMase deficiency is the underlying cause of the genetic diseases Niemann-Pick Type A and B and has been implicated
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