G6752

Guanosine

≥98%

• Sinonimo/i: 9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside
• Formula empirica (notazione di Hill): C₁₀H₁₃N₅O₅
• Numero CAS: 118-00-3
• Peso molecolare: 283.24
• Beilstein: 625911
• Numero CE: 204-227-8
• Numero MDL: MFCD00010182
• Codice UNSPSC: 41106305
• ID PubChem: 24895268
• NACRES: NA.51

Proprietà

• Origine biologica: microbial
• Livello qualitativo: 100; 200
• Saggio: ≥98%
• Forma fisica: powder
• Punto di fusione: 250 °C (dec.) (lit.)
• Solubilità: formic acid:water (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• Stringa SMILE: [H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1; NYHBQMYGNKIUIF-UUOKFMHZSA-N

Descrizione

Descrizione generale

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Applicazioni

Guanosine has been used:

• as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)
• as a component of Mouse Embryonic Fibroblasts (MEFs) culture
• as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC

Azioni biochim/fisiol

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges