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Key Documents

SML1045

Sigma-Aldrich

Thiazovivin

≥98% (HPLC), powder, Rho Kinase inhibitor

Sinonimo/i:

N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide

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About This Item

Formula empirica (notazione di Hill):
C15H13N5OS
Numero CAS:
1226056-71-8
Peso molecolare:
311.36
Codice UNSPSC:
12352200
NACRES:
NA.77

product name

Thiazovivin, ≥98% (HPLC)

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

, white to beige to brown

Solubilità

DMSO: 20 mg/mL, clear

Temperatura di conservazione

−20°C

InChI

1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
DOBKQCZBPPCLEG-UHFFFAOYSA-N

Applicazioni

Thiazovivin has been used in the generation of induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) from human urine cells. It has also been used to study the the effect of pro-fibrotic inhibition on cardiac reprogramming.

Azioni biochim/fisiol

Thiazovivin is a Rho Kinase (ROCK) inhibitor that promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method when used in combination with ALK5 inhibitor SB-431542 (S4317) and MEK inhibitor PD-0325901 (PZ0162). Thiazovivin stabilizes E-cadherin on the cell surface, necessary for human embryonic stem cell survival in culture. When human embryonic stem cells are cut out from the colony, this key protein is disrupted and then internalized within the cell. Without e-cadherin on the cell surface, cell signaling between the cells and their environment is disrupted and the cells quickly die.
Thiazovivin is an inhibitor of Rho associated coiled-coil containing protein kinase (ROCK). In vitro studies prove that thiazovivin is efficient in stimulating better morphology, expression of ionic transporter and protein involved in cell adhesion.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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The ROCK inhibitor, thiazovivin, inhibits human corneal endothelial-to-mesenchymal transition/epithelial-to-mesenchymal transition and increases ionic transporter expression.
Wu Q, et al.
International Journal of Molecular Medicine, 40(4), 1009-1018 (2017)
Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol.
Cheng L, et al.
Frontiers in Molecular Neuroscience, 10, 348-348 (2017)
Yonatan R Lewis-Israeli et al.
Journal of visualized experiments : JoVE, (175) (2021-10-05)
The ability to study human cardiac development in health and disease is highly limited by the capacity to model the complexity of the human heart in vitro. Developing more efficient organ-like platforms that can model complex in vivo phenotypes, such
Jianbo Zhang et al.
Nature protocols, 16(8), 3874-3900 (2021-06-30)
The presence of microbes in the colon impacts host physiology. Therefore, microbes are being evaluated as potential treatments for colorectal diseases. Humanized model systems that enable robust culture of primary human intestinal cells with bacteria facilitate evaluation of potential treatments.
Ian T Fiddes et al.
Cell, 173(6), 1356-1369 (2018-06-02)
Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem cell proliferation and is a determinant of neuronal number in the mammalian cortex. We find that three paralogs of human-specific
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Articoli

Naive Pluripotent Stem Cell Culture in an Inhibitor Based 2i/LIF Containing Serum-Free and Feeder-Free Stem Cell Media

Development of a serum-free and feeder-free 2i naive stem cell media for pluripotent stem cells.

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