SML1018
Cyclosporin A
≥95% (HPLC), DMSO solution, calcineurin inhibitor
Sinonimo/i:
CsA, Cyclosporine
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About This Item
Formula empirica (notazione di Hill):
C62H111N11O12
Numero CAS:
Peso molecolare:
1202.61
Numero CE:
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Cyclosporin A, Ready Made Solution, 1 mg/mL in DMSO
Stato
DMSO solution
Livello qualitativo
Condizioni di stoccaggio
protect from light
Concentrazione
1 mg/mL in DMSO
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
InChI
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
PMATZTZNYRCHOR-IMVLJIQESA-N
Applicazioni
Cyclosporin A has been used to test its toxic effect on perfused 3D proximal tubule model.
Azioni biochim/fisiol
Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes. It has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+- and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. CsA was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes. At concentrations >10 nM, CsA protected isolated hepatocytes against the action of phalloidin. CsA can inhibit IL2 production resulting from T cell activation via Calcineurin inhibition.
An extensive list of references has been reported, including a comprehensive review of analytical properties.
An extensive list of references has been reported, including a comprehensive review of analytical properties.
Cyclosporin A is generally given subsequent to transplant surgery to prevent rejection. In addition to its beneficial effects in organ transplantation, cyclosporin (CyA) exhibits nephrotoxic side effects.
Altre note
Light sensitive
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
188.6 °F - closed cup
Punto d’infiammabilità (°C)
87 °C - closed cup
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