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C3662

Sigma-Aldrich

Cyclosporin A

from Tolypocladium inflatum, ≥95% (HPLC), solid, Calcineurin inhibitor

Sinonimo/i:

Antibiotic S 7481F1, Cyclosporine

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About This Item

Formula empirica (notazione di Hill):
C62H111N11O12
Numero CAS:
59865-13-3
Peso molecolare:
1202.61
Beilstein:
3647785
Numero MDL:
MFCD00274558
Codice UNSPSC:
12352200
ID PubChem:
24278028
NACRES:
NA.77

product name

Cyclosporin A, from Tolypocladium inflatum, ≥95% (HPLC), solid

Origine biologica

Tolypocladium inflatum

Livello qualitativo

300

Saggio

≥95% (HPLC)

Forma fisica

solid

Colore

white

Solubilità

dichloromethane: 10 mg/mL
ethanol: 10 mg/mL
DMSO: 50 mg/mL
chloroform: 6 mg/mL
H2O: insoluble

Spettro attività antibiotica

fungi

Modalità d’azione

enzyme | inhibits

Ideatore

Novartis

Temperatura di conservazione

2-8°C

Stringa SMILE

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
PMATZTZNYRCHOR-CGLBZJNRSA-N

Informazioni sul gene

human ... PPIA(5478) , PPP3CA(5530) , PPP3CB(5532) , PPP3CC(5533) , PPP3R1(5534) , PPP3R2(5535)

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Azioni biochim/fisiol

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H350,H360FD

Classi di pericolo

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Sigma-Aldrich

F4679

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Sigma-Aldrich

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Gβγ Modulator II, Gallein A cell-permeable xanthene compound that binds to Gβγ with high affinity (Kd ~400 nM derived from a surface plasma resonance binding study using Gβ1γ2) and blocks Gβγ-dependent cellular activities.

Sigma-Aldrich

371708

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Cyclosporin D solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

C-108

Cyclosporin D solution

Mycophenolate mofetil ≥98% (HPLC)

Sigma-Aldrich

SML0284

Mycophenolate mofetil

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