SML0704

1-Methylnicotinamide chloride

≥98% (HPLC)

• Sinonimo/i: 3-Carbamyl-1-methylpyridinium chloride, MNA, N-Methylnicotinic acid amide chloride, N1-Methylnicotinamide chloride
• Formula empirica (notazione di Hill): C₇H₉ClN₂O
• Numero CAS: 1005-24-9
• Peso molecolare: 172.61
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: H₂O: 15 mg/mL, clear
• Temperatura di conservazione: room temp
• InChI: 1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H; BWVDQVQUNNBTLK-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable