SML2832

5-Amino-1-methylquinolinium iodide

≥98% (HPLC)

• Sinonimo/i: 5-Amino-1-MQ iodide, 5-Amino-1-methylquinolinium, iodide (1:1), 5-Amino-1MQ iodide
• Formula empirica (notazione di Hill): C₁₀H₁₁N₂·I
• Numero CAS: 42464-96-0
• Peso molecolare: 286.11
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: faint red to dark brown
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: C[N+]1=CC=CC2=C(C=CC=C12)N.[I-]

Descrizione

Azioni biochim/fisiol

5-Amino-1-methylquinolinium (5-amino-1MQ) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC₅₀ = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC₅₀ = 30μM) and adipocytes 1-methylnicotinamide level (EC₅₀ = 2.3 μM) without affecting related methyltransferases & enzymes in the NAD+ salvage pathway. 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid. sc.), and intraperitoneal HeyA8 ovarian cancer metastasis (20 mg/kg/d ip.) with no adverse effects to the animals (up to 60 mg/kg/d). Note:1.89 mg iodide salt contains 1 mg eq of 5-amino-1MQ.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable