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SML0307

Sigma-Aldrich

Pleconaril

≥98% (HPLC)

Sinonimo/i:

3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole, VP 63843, Win 63843

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About This Item

Formula empirica (notazione di Hill):
C18H18F3N3O3
Numero CAS:
153168-05-9
Peso molecolare:
381.35
Numero MDL:
MFCD00923611
Codice UNSPSC:
12352200
ID PubChem:
329825312
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: ≥10 mg/mL (warmed)

Temperatura di conservazione

room temp

Stringa SMILE

Cc1cc(CCCOc2c(C)cc(cc2C)-c3noc(n3)C(F)(F)F)on1

InChI

1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
KQOXLKOJHVFTRN-UHFFFAOYSA-N

Descrizione generale

Pleconaril is a drug, that has antiviral activity.

Applicazioni

Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.

Azioni biochim/fisiol

Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.
Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. Also, pleconaril delays the onset of diabetes in experimental animals infected with Ljungan virus (LV).
Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H413

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Chronic 4

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
037M4739V
016M4759V
114M4749V
093M4722V
032M4747V

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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Viral infections
Textbook of Clinical Neurology (Third Edition), 919-942 (2007)
A novel series of highly potent small molecule inhibitors of rhinovirus replication
Kim J, et al.
Journal of Medicinal Chemistry, 60(13), 5472-5492 (2017)
Microscopic determination of drug solubility in plasma and calculation of injection rates with a plasma circulatory model to prevent precipitation on intravenous injection.
G A Portmann et al.
Journal of pharmaceutical and biomedical analysis, 13(9), 1189-1193 (1995-08-01)
Chronic meningoencephalitis caused by Echo virus 6 in a patient with common variable immunodeficiency
Radanovic I, et al.
Wiener Klinische Wochenschrift, 130(1-2), 70-72 (2018)
Chunlong Ma et al.
ACS infectious diseases, 5(11), 1952-1962 (2019-09-19)
Enterovirus D68 (EV-D68) is a respiratory viral pathogen that primarily infects children under the age of 8. Although EV-D68 infection typically leads to moderate to severe respiratory illnesses, recent years have seen increasing cases of EV-D68 triggered neurological complications such
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