SML0031
DBeQ
≥98% (HPLC)
Sinonimo/i:
JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine
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About This Item
Formula empirica (notazione di Hill):
C22H20N4
Numero CAS:
Peso molecolare:
340.42
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Saggio
≥98% (HPLC)
Stato
powder
Colore
white to beige
Solubilità
DMSO: ≥20 mg/mL
Temperatura di conservazione
room temp
Stringa SMILE
C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4
InChI
1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
QAIMUUJJAJBPCL-UHFFFAOYSA-N
Categorie correlate
Applicazioni
HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.
Azioni biochim/fisiol
ATPase p97 inhibitor.
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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