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Merck
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Documenti fondamentali

SCP0110

Sigma-Aldrich

Cathepsin L Inhibitor

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About This Item

Formula empirica (notazione di Hill):
C35H59N11O5
Peso molecolare:
713.91
Codice UNSPSC:
12352200
NACRES:
NA.32

Saggio

≥95% (HPLC)

Stato

lyophilized

Composizione

Peptide Content, ≥55%

Condizioni di stoccaggio

protect from light

Temperatura di conservazione

−20°C

Amino Acid Sequence

Arg-Lys-Leu-Leu-Trp-NH2

Descrizione generale

Cathepsin L Inhibitor is a histone H3-processing enzyme. It is important for maintaining epidermal homeostasis, regular hair follicle morphogenesis and cycling. Cathepsin L is involved in protein degradation. It might regulate normal functioning of the immune system. Cathepsin L regulates the death of macrophages, necrotic core formation and development of atherosclerotic plaque instability.

Applicazioni

Cathepsin L is a lysosomal cysteine proteinase that metabolizes collagens and elastins. The roles and activity of Cathepsin L can be studied with the aid of peptide inhibitors such as the pentapeptide amide RKLLW-NH2 (Arg-Lys-Leu-Leu-Trp-NH2).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
CN0623

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Cathepsin K Inhibitor I The Cathepsin K Inhibitor I controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

219377

Cathepsin K Inhibitor I

Cathepsin L from human liver ≥0.5 units/mg protein, solution

Sigma-Aldrich

C6854

Cathepsin L from human liver

Cathepsin L Active human recombinant, expressed in FreeStyle™ 293-F cells, ≥90% (SDS-PAGE)

Sigma-Aldrich

SRP0291

Cathepsin L Active human

Pitstop 2 ≥98% (HPLC)

Sigma-Aldrich

SML1169

Pitstop 2

CA-074 ≥98% (HPLC)

Sigma-Aldrich

C5732

CA-074

E-64 protease inhibitor

Sigma-Aldrich

E3132

E-64

Protease signalling: the cutting edge
Turk B, et al.
The Embo Journal, 31(7), 1630-1643 (2012)
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
Liu J, et al.
Atherosclerosis, 184(2), 302-311 (2006)
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis
Li W, et al.
Atherosclerosis, 202(1), 92-102 (2009)
V Turk et al.
The EMBO journal, 20(17), 4629-4633 (2001-09-05)
From their discovery in the first half of the 20th century, lysosomal cysteine proteases have come a long way: from being the enzymes non-selectively degrading proteins in lysosomes to being those responsible for a number of important cellular processes. Some
A Brinker et al.
European journal of biochemistry, 267(16), 5085-5092 (2000-08-10)
By screening a combinatorial pentapeptide amide collection in an inhibition assay, we systematically evaluated the potential of 19 proteinogenic amino acids and seven nonproteinogenic amino acids to serve as building blocks for inhibitors of human cathepsin L. Particularly efficient were

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