SAB4700671
Monoclonal Anti-KRT18-Biotin antibody produced in mouse
clone DC-10, purified immunoglobulin, buffered aqueous solution
Sinonimo/i:
Anti-Cytokeratin 18
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Clone:
DC-10, monoclonal
application:
FACS
Reattività contro le specie:
human
tecniche:
flow cytometry: suitable
citations:
5
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
biotin conjugate
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
DC-10, monoclonal
Stato
buffered aqueous solution
Reattività contro le specie
human
Concentrazione
1 mg/mL
tecniche
flow cytometry: suitable
Isotipo
IgG1
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... KRT18(3875)
Descrizione generale
Keratin 18 (KRT 18) or cytokeratin 18 (CK18) encodes the type I intermediate filament chain keratin 18. The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues. In human chromosome, the gene KRT18 is localized on 12q13.13.
Immunogeno
Human breast carcinoma cell line PMC-42
Applicazioni
The reagent is designed for Flow Cytometry. Suggested working dilution is 1:500. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Azioni biochim/fisiol
Keratin 18 (KRT18/CK18) pairs with CK8 to form the intermediate filaments and maintain the integrity in hepatocytes. CK18 associates with histone H3 in the progression of hepatocellular carcinoma (HCC). Disorganization or altered levels of CK18 is related to plectin deficiency in HCC. K18 may be a marker for liver diseases. K18 is present in Mallory bodies and is elevated in alcoholic cirrhosis and alcoholic hepatitis. K18 expression is modulated by interleukin 6 (IL-6). K18 interacts with desmosomal protein/ E-cadherin and promotes cell adhesion. CK18 is cleaved by caspases during apoptosis and released into blood as caspase cleaved cytokeratin-18 (CCCK18).
Caratteristiche e vantaggi
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Stato fisico
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
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Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Cell death and prognosis of mortality in alcoholic hepatitis patients using plasma keratin-18
Woolbright BL, et al.
Gene Expression, 17(4), 301-312 (2017)
Interleukin-6 Induces keratin expression in intestinal epithelial cells potential role of Keratin-8 in interleukin-6-induced barrier function alterations
Wang L, et al.
The Journal of Biological Chemistry, 282(11), 8219-8227 (2007)
High serum levels of caspase-cleaved cytokeratin-18 are associated with malignant middle cerebral artery infarction patient mortality
Lorente L, et al.
BMC Neurology, 18(1), 32-32 (2018)
Cytokeratin 18-associated Histone 3 Modulation in Hepatocellular Carcinoma: A Mini Review
Lai YCC, et al.
Cancer, Genomics, and Proteomics, 14(4), 219-223 (2017)
TP53 mutation, epithelial-mesenchymal transition, and stem like features in breast cancer subtypes
Coradini D, et al.
BioMed Research International, 2012 (2012)
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