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Key Documents

SAB4300213

Sigma-Aldrich

Anti-phospho-H2AFX (pSer139) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-H2A histone family, member X antibody produced in rabbit, Anti-H2A.X antibody produced in rabbit, Anti-H2A/X antibody produced in rabbit, Anti-H2AX antibody produced in rabbit

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About This Item

Numero MDL:
MFCD07370338
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

~15 kDa

Reattività contro le specie

human

Concentrazione

1 mg/mL

tecniche

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

Isotipo

IgG

Sequenza immunogenica

(Q-A-SP-Q-E)

N° accesso NCBI

NP_002096.1

N° accesso UniProt

P16104

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

phosphorylation (pSer139)

Informazioni sul gene

human ... H2AFX(3014)

Categorie correlate

Immunogeno

Peptide sequence around phosphorylation site of serine 139 (Q-A-S(p)-Q-E), according to the protein H2AFX.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrizione del bersaglio

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Anticorpo anti fosfo-istone H2A.X (Ser139), colone JBW301

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