SAB4200182

Anti-Glutathione Reductase antibody, Mouse monoclonal

clone GR6, purified from hybridoma cell culture

• Sinonimo/i: Anti-GR, Anti-GSR, Anti-Glutathione-disulfide reductase, Anti-NADPH:oxidized glutathione oxidoreductase
• Numero MDL: MFCD01323367
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: purified from hybridoma cell culture
• Tipo di anticorpo: primary antibodies
• Clone: GR6, monoclonal
• Stato: buffered aqueous solution
• PM: antigen ~55 kDa
• Reattività contro le specie: human
• Concentrazione: ~1.0 mg/mL
• tecniche: immunoprecipitation (IP): suitable; western blot: 2-4 μg/mL using whole extracts of human HepG2 cells.
• Isotipo: IgG1
• N° accesso UniProt: P00390
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... GSR(2936)

Descrizione

Descrizione generale

Monoclonal Anti-Glutathione Reductase (mouse IgG1 isotype) is derived from the hybridoma GR6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a human Glutathione reductase recombinant protein. Glutathione reductase is a homodimeric enzyme containing one FAD molecule and NADPH binding domain per subunit. This gene is located on human chromosome 8p.

Immunogeno

mice immunized with a human Glutathione reductase recombinant protein. The corresponding proteins in rat and mouse share 86% and 85% homology, respectively.

Applicazioni

Monoclonal Anti-Glutathione Reductase antibody produced in mouse has been used in:

• immunohistochemical
• immunofluorescence studies
• immunoblotting
• immunoprecipitation

Azioni biochim/fisiol

Glutathione reductase (GR) is a ubiquitous flavoenzyme involved in protecting cells from stress. GR catalyses the reduction of oxidized glutathione (GSSG) to glutathione (GSH). It is an essential component of the glutathione redox cycle, which maintains adequate levels of reduced cellular GSH. GSH serves as an antioxidant and also as an electron donor for glutathione peroxidases and a substrate for glutathione-S-transferases.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable