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R0283

Sigma-Aldrich

Ropivacaine hydrochloride monohydrate

≥98% (HPLC)

Sinonimo/i:

(2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate, (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate, Naropin hydrochloride monohydrate

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About This Item

Formula empirica (notazione di Hill):
C17H26N2O · HCl · H2O
Numero CAS:
132112-35-7
Peso molecolare:
328.88
Numero MDL:
MFCD00946578
Codice UNSPSC:
12352203
ID PubChem:
329823983
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Attività ottica

[α]/D -9 to -12, c = 1 in methanol

Condizioni di stoccaggio

desiccated

Colore

white to off-white

Solubilità

H2O: 5 mg/mL, clear

Ideatore

AstraZeneca

Temperatura di conservazione

2-8°C

Stringa SMILE

O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C

InChI

1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1
VSHFRHVKMYGBJL-CKUXDGONSA-N

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Descrizione generale

Ropivacaine has lidocaine-related structure with tertiary amine side chains. It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.

Applicazioni

Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

Azioni biochim/fisiol

Local anaesthetic with less cardiotoxicity than bupivacaine.
Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.
Ropivacaine less lipophilic as compared with bupivacaine. It is metabolized in the liver by the enzyme cytochrome P4501A2. Ropivacaine elicits less central nervous system (CNS) toxicity and is used as a local anaesthetic during postoperative and labour pain.

Caratteristiche e vantaggi

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H318

Consigli di prudenza

P280 - P305 + P351 + P338

Classi di pericolo

Eye Dam. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
114M4746V
063M4706V
050M4701

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Bupivacaina cloridrato United States Pharmacopeia (USP) Reference Standard

USP

1078507

Bupivacaina cloridrato

USP

USP

1605512

Ropivacaine Related Compound A

Lidocaine powder

Sigma-Aldrich

L7757

Lidocaine

P Lirk et al.
British journal of anaesthesia, 113 Suppl 1, i32-i38 (2014-06-21)
Lidocaine demethylates deoxyribonucleic acid (DNA) in breast cancer cells. This modification of epigenetic information may be of therapeutic relevance in the perioperative period, because a decrease in methylation can reactivate tumour suppressor genes and inhibit tumour growth. The objectives of
Yuzhuo Wang et al.
International journal of cancer, 142(8), 1602-1610 (2017-12-02)
Traditional pathway analysis map single nucleotide polymorphisms (SNPs) to genes according to physical position, which lacks sufficient biological bases. Here, we incorporated genetics of gene expression into gene- and pathway-based analysis to identify genes and pathways associated with lung cancer
Jian Zhang et al.
Scientific reports, 8(1), 14181-14181 (2018-09-23)
The purpose of this study is to explore Dvl3 variants and their interaction with negative life events on MDD susceptibility in a Chinese Han population. Additionally, we also attempted to identify whether there is an association between Dvl3 variants and

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